INSIDE THE CURRENT ISSUE

October 2012

Infection Prevention

Infection Control Update

New antibacterial coating for sutures could reduce infections after surgery

Responding to an urgent need for better antibacterial coatings on surgical sutures, scientists are reporting the discovery of a new coating that is almost 1,000 times more effective than the most widely used commercial coating. Their report appears in ACS’ journal Langmuir.

Professor Gregory Tew, who is from UMass-Amherst, and colleagues explain that infection at the site of surgical incisions is one of the most common post-surgical complications that keep patients hospitalized longer and boost hospital bills.

The most common antibiotic coating contains triclosan, but its use in many consumer products over the years has led to the emergence of strains of bacteria that shrug off its effects. Triclosan also can be absorbed into the body, raising concerns about possible adverse health effects. Another downside to triclosan: It slows the growth of bacteria, but does not actually kill those already present.

That’s why the scientists turned to PAMBM, a new substance designed from naturally occurring antimicrobial peptides that can kill a wide range of bacteria. And because of the way it works, PAMBM has a very low chance of causing bacterial resistance and the emergence of so-called superbugs.

The report described laboratory tests in which PAMBM greatly reduced the amount of bacteria compared to triclosan. In a head-to-head test with triclosan-coated sutures, those coated with PAMBM were much more effective against bacteria. "As bacterial resistance to current agents continues to increase and with resistance to triclosan now documented, the discovery of new antimicrobial agents that remain active in biomedical device coatings is essential," say the researchers.

Study reveals alarming levels of drug-resistant tuberculosis

"Most international recommendations for TB control have been developed for MDR TB prevalence of up to around 5%. Yet now we face prevalence up to ten times higher in some places, where almost half of the patients with infectious disease are transmitting MDR strains", warns Sven Hoffner from the Swedish Institute for Communicable Disease Control in a linked Comment.

"Drug-resistant TB is more difficult and costly to treat, and more often fatal. Internationally, it is particularly worrisome in areas with fewer resources and less access to effective therapies. As more individuals are diagnosed with, and treated for, drug-resistant TB, more resistance to second-line drugs is expected to emerge," explains Tracy Dalton, the study’s lead author from the US Centers for Disease Control and Prevention. "So far, XDR TB has been reported in 77 countries worldwide, but exact prevalence remains unclear."

The prevalence of resistance varied widely between countries. Overall, resistance to any second-line drug was detected in nearly 44% of patients, ranging from 33% in Thailand to 62% in Latvia. In a fifth of cases resistance to at least one second-line injectable drug was identified, ranging from 2% in the Philippines to 47% in Latvia. (Lancet)

 

Healthcare facilities strive to hand infections defeat

by Susan Cantrell, ELS

There is an old Lebanese proverb that still offers sound advice for us today: "Hygiene is two thirds of health." Never is that truer than in the healthcare setting.

It is common knowledge that good hand hygiene is a key to wellness, both at home and in the medical setting. That’s why the results of a study published in December 2011 in the American Journal of Infection Control is so disturbing.1 Eighty-five medical students were surveyed in their third year of study, their first year with clinical contact. Seven scenarios, of which 5 were correct hand-hygiene indications, were given: before patient contact, before preparation of infusions, after removal of gloves, after contact with the patient’s bed, and after contact with vomit. Sadly, only 33% of the students correctly identified all 5 true indications, and only 21% correctly identified all 5 true and 2 false indications. If these 85 students are a typical representation of our future healthcare workers (HCWs), we could be in trouble.

Scientific evidence on the value of clean hands has been accumulating since the early 1800s. Centers for Disease Control and Prevention (CDC) has been publishing handwashing guidelines since 1975. J. Hudson Garrett, Jr., PhD, MSN, MPH, FNP-BC, CSRN, VA-BC, senior director, clinical affairs, PDI Inc., Orangeburg, NY, noted, "Hand hygiene is widely accepted as the most critical infection-prevention intervention in modern medicine." Yet, compliance with hand-hygiene protocol remains an issue.

One reason for noncompliance that always floats to the top when hand hygiene is under discussion is skin damage caused by frequent hand cleansing. That is a genuine concern. Skin damage is painful, making compliance less likely. The skin can become so dry that it feels like it is burning; it can appear red and feel rough to the touch. Skin damage presents an infection risk because dry, fissured skin offers hiding and breeding places for pathogenic organisms that can be transferred from the caregiver to the patient or the environment.

The CDC’s hand-hygiene guideline states, "...approximately 25% of nurses report symptoms or signs of dermatitis involving their hands, and as many as 85% give a history of having skin problems. Frequent and repeated use of hand-hygiene products, particularly soaps and other detergents, is a primary cause of chronic irritant contact dermatitis among HCWs." The good news from CDC is "The potential of detergents to cause skin irritation can vary considerably and can be ameliorated by the addition of emollients and humectants."

Ecolab Revitalizing Skin Lotion

For the caregiver

Industry grasps the problem. Linda Homan, RN, BSN, CIC, senior manager, clinical and professional service, Ecolab, St. Paul, MN stated, "One of the most important factors driving hand-hygiene compliance is providing products that are not harsh or damaging to the skin, so HCWs want to use them. At Ecolab, we formulate our hand sanitizers, such as our Quik-Care Foam Waterless Hand Sanitizer, and soap products to include skin conditioners and emollients that help moisturize and improve skin health with continued use. We also recommend that healthcare facilities provide hospital-grade hand lotions to prevent skin damage. For example, our Revitalizing Skin Lotion is a CHG [chlorhexidine gluconate]-compatible moisturizing lotion that does not compromise the antimicrobial efficacy of CHG scrubs and is compatible with latex and non-latex gloves."

One complaint often heard by users is that they do not like how a product feels on their hands, so they do not want to use it. Ecolab heard that complaint and responded. "Ecolab hand sanitizers are formulated to dry within seconds and not leave a sticky feeling on skin, which reduces application time and encourages use," said Homan. "In addition to products that are gentle but effective, we have found that a combination of products, dispensers, education, training, and a monitoring system that provides immediate feedback and positively reinforces behavior without interfering with an HCW’s daily routine, also drives compliance."

Homan also cited scientific evidence in support of Ecolab’s product claims. "A poster presented at the APIC [Association for Professionals in Infection Control and Epidemiology Inc.] annual conference in June described how the combination of the right products and automated monitoring can drive improvement. Working with Ecolab, Southern Alabama’s Andalusia Regional Hospital implemented a hand-hygiene monitoring system that tracked use of both hand sanitizer and soap. Over a 6-month period, hand sanitizer and soap dispenses increased by 82.6%. In addition, patient responses to a question about their perception of HCW hand cleansing demonstrated a 9% increase in the perception that HCWs ‘always’ performed hand hygiene."2

Kindest Kare Foamed Antiseptic Handrub
from STERIS

STERIS Corporation, Mentor, OH, also believes in the power of emollients. STERIS Kindest Kare Foamed Antiseptic Handrub with Enhanced Emollients is a high-performance formulation designed specifically for healthcare professionals, to encourage frequent use in hospitals and health facilities. It is a mild yet effective foamed handrub that moisturizes hands, as well as a lotion, while eliminating 99.9999% of most common organisms. It contains 62% ethyl alcohol, and, when tested on human skin, this exclusive professional healthcare formula meets Food and Drug Administration (FDA)’s Healthcare Personnel Handwash and Surgical Scrub criteria on both the first and the tenth wash. It is used with either a manual or touchless wall-mounted dispenser that creates quality foam.

Laura Ball, infection prevention product manager, Kimberly-Clark, Roswell, GA, talked to Healthcare Purchasing News about some of their moisturizing hand-care products. "Kleenex ULTRA Moisturizing Foam Hand Sanitizer uses natural cucumber and green tea extracts to moisturize skin for up to 2 hours after application. In addition, tests show that it improves skin hydration by 30%, and it is clinically proven to improve skin condition in less than 5 days, leaving skin feeling soft and smooth, while maintaining efficacy against the most common bacteria that can contaminate surfaces and cause infection. Research conducted by Kimberly-Clark found that two out of three nurses prefer the Kleenex ULTRA Moisturizing Foam Hand Sanitizer over Purell Advanced Skin Nourishing Foam."

Kleenex Ultra Moisturizing Foam Hand Sanitizer from Kimberly-Clark

Ball mentioned other advantages of Kleenex ULTRA Moisturizing Foam Hand Sanitizer that make it attractive to HCWs. It "dries fast, and the proprietary moisturizing formula reduces the sticky feel users experience after multiple uses with other hand sanitizers, while improving skin hydration to leave hands feeling nourished and healthy. It is compatible with latex, nitrile, and vinyl gloves and has a 70% alcohol content, which is effective against the most common bacteria and fungi that can contaminate surfaces and cause infection. It is cost-effective, as it delivers nearly twice the number of shots as gel products of the same size."

fiteBac SkinCare, LLC, Fort Worth, TX, a subsidiary of Kimmerling Holdings Group, LLC, recently launched a new hand sanitizer, fiteBac SkinCare Germicidal Hand Softening Gel, which they believe will help reverse the trend of skin damage associated with frequent handwashing. Former Dow Corning chemist John Blizzard wanted to create a sanitizer that lacked the harmful side effects linked to other traditional hand sanitizers. fiteBac Gel is paraffin-free, water-free, unscented, petroleum-free, and alcohol-free. The patent-pending technology is comprised of a non-alcohol–based antimicrobial formulation and a silicone-based cross polymer that provides hydrophobic properties to improve the skin’s moisture barrier and keep the skin soft, even after frequent handwashing or glove use.

Germgard Lighting, LLC, Dover, NJ, does not yet ship commercialized products, but it is working on a different approach to hand cleansing. Their goal is to provide a suite of less expensive, faster working, and better infection-prevention and contamination-control solutions. The products under development employ UV-C technologies and optical materials for sanitation of both bare and gloved hands. Germgard Lighting’s UV-C hand sanitizer and its suite of hand-protection products is expected to have the potential to improve upon the efficacy, lengthy application time, and irritation associated with handwashing.

For the patient

Patients often cannot ambulate to a sink to clean their hands. Garrett described how PDI’s products take into consideration their needs. "Sani-Hands Instant Hand Sanitizing Wipes contain aloe and vitamin E, which has been clinically proven to moisturize the skin with repeated use. The antimicrobial gel rub is enhanced by the friction of the wipe, physically removing more soil from hands than traditional gels and foams, without leaving a sticky or greasy residue. Sani-Hands contain 65.9% alcohol, which exceeds CDC and WHO [World Health Organization] requirements for alcohol content in hand-hygiene products in healthcare settings, and kills 99.99% of bacteria."

PDI Sani-Hands wipes family

Sani-Hands Instant Hand Sanitizing Wipes are packaged in quick-pull canisters and individual packets, which make them convenient for meal trays and overbed tables. "The Sani-Hands Bedside Pack is specifically designed to aid patients, whether bedbound or ambulatory, in proper hand hygiene," said Garrett. "Each pack contains 20 large wipes, ideal for an average patient stay of 3 days in most inpatient facilities. All Sani-Hands are fragrance-free and dye-free, which allow them to be used on the most sensitive patient populations; are FDA Food Code-compliant, making them safe for use prior to eating; and contain moisturizers and emollients to ensure that hands are not dried out with repeated use."

"PDI also offers optional point-of-care/-use dispensing accessories for use with Sani-Hands products, including Sani-Bracket wall and mobile-equipment brackets and Infection Prevention Pak," said Garrett. "These are designed to aid in compliance with regulatory and accreditation requirements for engaging the patient and their family in their own care."

"Sani-Hands has been used by hospitals to support a patient hand-hygiene program to reduce the spread of healthcare-acquired infections," said Garrett. He related an experience that took place in 2009 at a 100+ bed, high-acuity, long-term–care facility in Pennsylvania, which implemented a multidisciplinary infection-prevention program that targeted a thorough environmental-disinfection program using Super Sani-Cloth/Sani-Cloth Bleach and also a healthcare provider-/resident-centered hand-hygiene program using Sani-Hands. "The 6-month study resulted in HAI rates dropping by 77%, a decrease in acute-care transfers due to infection treatment needed by 22 transfers, and, most significantly, a $33K decrease in the costs of antibiotics for treatment of resident infections as compared to the previous year," said Garrett. "This program not only resulted in decreased costs, but also became part of the facility’s antimicrobial stewardship program."

For the OR

Surgicept Waterless Surgical Hand Scrub
from CareFusion

Susie Wolf, senior product manager of hand-scrub solutions, CareFusion, San Diego, CA, also highlighted the importance of selecting products liked by staff, because staff preference can have a great impact on compliance with hand-hygiene protocol. "A study has shown that, if healthcare practitioners don’t feel comfortable with a product, they are not likely to use it consistently," said Wolf.3

"A nationwide blind study of healthcare professionals showed the ingredients and formulation of Surgicept may address some of the factors related to the failure to adhere to surgical hand-scrub protocols. Nearly 80% of the surgeons and OR [operating room] staff preferred Surgicept to the current leading waterless surgical hand antiseptic (Surgical-scrub comparison market research, Bernstein-Rein, 2010). Participants found Surgicept to be significantly more appealing and noted its soft, smooth feel and quick drying time. Surgicept dried two times faster than the comparative product. In addition to overall preference, more participants favored Surgicept on specific attributes that could have a positive effect on compliance, including easier gloving, quicker dry time, less residue on the skin, and an easier application process. The faster dry time leads to shorter overall application time, which can lead to better adherence to hand-hygiene guidelines."

"We developed the Surgicept formulation to address the complaints from surgical staff about the feel, longer drying time, and stickiness of current surgical-scrub products," said Shanta M. Modak, PhD, research scientist, Columbia University Medical Center, New York, NY, and inventor of Surgicept. "I believe that Surgicept will make hand hygiene more comfortable for healthcare professionals and therefore has the potential to increase compliance."

Wolf added that Surgicept’s formula exceeds FDA-required surgical hand-scrub testing standards for immediate, persistent, and cumulative reductions in resident and transient flora.

Those working in the OR traditionally scrub their hands and nails with a brush or sponge, which can contribute to skin damage. Greg F. Skorczewski, technical specialist, 3M, St. Paul, MN, explained how their products can offer an advantage over the traditional approach. "In the OR, skin damage can occur from traditional surgical-scrub methods that use a brush or sponge. 3M developed Avagard (chlorhexidine gluconate 1% solution and ethyl alcohol 61% w/w) Surgical and Healthcare Personnel Hand Antiseptic with Moisturizers as a fast and effective alternative to a traditional 6-minute surgical scrub. The unique formulation combines alcohol for immediate antimicrobial kill and chlorhexidine gluconate for persistence, and is delivered in an emollient-rich lotion base to help maintain skin integrity."

3M Avagard Hand Antiseptic with Moisturizers in hands-free wall dispenser

"The Avagard Surgical Antiseptic application is a three-step process that is performed in a fraction of the time of a traditional scrub," continued Skorczewski. "In addition, its dual active formulation of alcohol and active levels of chlorhexidine gluconate provides cumulative and superior persistent antimicrobial activity as compared to products whose only active ingredient is alcohol."4

"3M also provides Avagard D Instant Hand Antiseptic with Moisturizers as a personnel healthcare handwash option," said Skorczewski. "With the increased awareness and emphasis on sustained hand-hygiene compliance, HCWs have been faced with a significant increase in hand-hygiene opportunities. Avagard D Instant Hand Antiseptic has a unique advanced liquid-crystalline moisturizing formulation that helps prevent dryness and maintain skin integrity."

Compliance monitoring

Some facilities have boosted their performance by monitoring HCWs for compliance at hand-hygiene opportunities. There are a number of monitoring systems, including the traditional one of observance. The trend now is toward technological solutions. "Direct observation has many disadvantages," said Paul Alper, vice president, strategy and business development, Deb Worldwide Healthcare Inc., Charlotte, NC. "It only captures a small sampling of hand-hygiene events; people act differently when they know they are being watched, the Hawthorne Effect; it is not timely; and it is expensive."

DebMed GMS hand-hygiene compliance reports

Alper explained how their solution works. "The DebMed GMS (group monitoring system) is the world’s first electronic monitoring system to report hand-hygiene compliance rates based on the WHO’s Five Moments for Hand Hygiene," said Alper. "When a soap or sanitizer dispenser is used, a wireless signal is sent, indicating that a hand-hygiene event has occurred. The hand-hygiene events are compared to how many hand-hygiene events should have taken place, based on the breakthrough ‘HOW2 Benchmark Study,’ published in the American Journal of Infection Control in February 2011.5 This research established statistically significant numbers of hand-hygiene opportunities in various types of units in different hospital settings. Proprietary data from each hospital using the system is added to this calculation to ‘calibrate’ the compliance rate so that it is specific to that hospital. Compliance reports are available via the Web."

Other advantages of the DebMed GMS is that "the system does not require a real-time location system or radio-frequency identification infrastructure, does not interfere with existing systems, and requires no capital investment," said Alper. "The DebMed GMS captures 100% of hand-hygiene events, eliminates the Hawthorne Effect, provides compliance reports in real-time, and is the most cost-effective system on the market. The system monitors compliance at the group level to encourage collaboration, rather than singling out individuals, and includes an online toolkit to help support behavior change."

Alper also talked about cost savings experienced by users of DebMed. "A study conducted at Duke University Medical Center, published in Infection Control and Hospital Epidemiology, showed that minimal improvements in compliance lead to substantial savings, concluding that a 1% increase in hand-hygiene compliance would result in annual savings of $39,650 to a 200-bed hospital.6 One DebMed user, the Greenville Hospital System, Greenville, SC, was able to increase unit-based hand-hygiene compliance significantly upon implementing the program."

Irisys was awarded a contract from U.K. National Institute for Health Research last year to develop sensors to improve handwash compliance rates. The compliance monitoring system, currently being trialed in the United Kingdom, uses thermal sensors to detect movement of people, around the clock and without invading their privacy, and determines an accurate count of handwash opportunities. It then compares those opportunities with handwash occurrences. Use of sanitizing gel hand-rub or soap dispensers also is monitored. Combined with communication and reporting systems, the resulting solution is expected to be an affordable, non-intrusive technology that could cut infection rates.

UltraClenz (Jupiter, FL) Patient Safeguard System offers a real-time monitoring system. Here’s how it works. The system is comprised of a badge, a dispenser beacon, and a wireless communication system. The badge communicates with the dispenser beacon, and the information is sent to the Bentley Wireless Communication System. Notification of the caregiver’s hand-hygiene status is communicated to the floor supervisor on a computer or tablet device. The badge displays whether the caregiver is compliant (green light), needs to be aware that a situation requires compliance (yellow light), or whether the caregiver is noncompliant (red light). The caregiver’s badge displays a green light when he or she sanitizes or washes his or her hands. The yellow light comes on, as a reminder, when the caregiver approaches a patient’s bed. If the caregiver does not clean his or hands at appropriate times, a red light flashes on the badge and a repetitive, audible alert is sounded. For more detailed information on the UltraClenz Patient Safeguard System, go to http://www.ultraclenz.com.

Complex yet simple

While the topic of hand hygiene in healthcare is definitely not child’s play, it is so simple a concept that even children can convey this important message effectively. During their recent annual meeting, APIC awarded first place in their second annual Film Festival to the video "Scrub-a-Dub Dub," performed by rapping 10-year-old twin brothers Jerry and Josie Herman. Jerry spent several months as an intensive-care patient at All Children’s Hospital in St. Petersburg, FL, the source of the video. The video reinforces proper hand-hygiene technique for healthcare professionals and encourages patients and families to be involved in this important infection-prevention strategy. The video’s chorus says, "We don’t care if you’re a doctor, a parent, or nurse; if you’ve got patient contact, you wash your hands first!" The video concludes with step-by-step instructions in best practices for handwashing. To see the video, go to http://www.youtube.com/watch?v=ItPrIK5eh-Q&feature=youtu.be.

 

References

1. Graf K, Chaberny IF, Vonberg R-P. Beliefs about hand hygiene: a survey in medical students in their first clinical year. Am J Infect Control 2011;39(10):885-888.

2. Northey CB, Improving hand hygiene practice through utilization of automated hand hygiene monitoring and feedback technology. Poster presented at the Annual Association of Professionals in Infection Control and Epidemiology Educational Conference and International Meeting; June 2012; San Antonio, TX.

3. Centers for Disease Control and Prevention. Guideline for hand hygiene in health-care settings: recommendations of the Healthcare Infection Control Practices Advisory Committee and the HICPAC/SHEA/APIC/IDSA Hand Hygiene Task Force. MMWR 2002;51(No. RR-16):[inclusive page numbers].

4. Olson LK, Morse DJ, Duley C, Savell BK. Prospective, randomized in vivo comparison of a dual-active waterless antiseptic versus two alcohol-only waterless antiseptics for surgical hand antisepsis. Am J Infect Control 2012;40(2):155-159.

5. Steed C, Kelly JW, Blackhurst D, Boeker S, Diller T, Alper P, et al. Hospital hand hygiene opportunities: where and when (HOW2)? The HOW2 Benchmark Study. Am J Infect Control 2011;39(1):19-26.

6. Cummings KL, Anderson DJ, Kaye KS. Hand hygiene noncompliance and the cost of hospital-acquired methicillin-resistant Staphylococcus aureus infection. Infect Control Hosp Epidemiol. 2010;31(4):357-364.