Millions of Americans with Hepatitis C Not Receiving Antiviral Drugs That Cure Disease

Prescribing rates rose rapidly when the drugs were introduced in 2013, but they have fallen sharply since then.
April 21, 2026

Key Highlights

  • - Prescription rates for hepatitis C drugs peaked in 2015 but have declined sharply in recent years.
  • - An estimated four million Americans live with chronic hepatitis C, many unaware of their infection.
  • - Restrictions like Medicaid's early limitations and low awareness contribute to the treatment gap.
  • - Experts recommend administering roughly 260,000 treatment courses annually to meet elimination goals.
  • - The decline in prescriptions threatens progress toward eradicating hepatitis C in the United States.

Researchers looked at prescribing trends for hepatitis C patients and determined that “millions of Americans…could be cured [of the disease] with antiviral drugs they are not receiving.”

Prescriptions rose “rapidly when the drugs were first introduced in 2013, then peaked in 2015. After that, use began to decline and has fallen sharply in recent years.”

Hepatitis C is most often spread through the U.S. by drug use, but it can “also spread from a mother to her child during birth and, less commonly, through sexual activity. Many people are unaware they have the virus because symptoms such as jaundice, fatigue, fever, and nausea don’t appear until significant liver damage has occurred. It’s estimated that up to four million Americans have chronic hepatitis C infections.”

In 2015, over 185,000 courses of the drugs were administered to patients. For 2025, however, that number had plummeted below 70,000. Medicaid restricted prescriptions to patients with advanced liver scarring in the drugs’ early days. Experts estimate that “roughly 260,000 treatment courses need to be administered each year to meet the national target to eliminate the virus.”

About the Author

Matt MacKenzie

Associate Editor

Matt is Associate Editor for Healthcare Purchasing News.

Sign up for our eNewsletters
Get the latest news and updates