Fewer Patients Went to EDs for C difficile Infections in 2024 Compared to 2014

These numbers show progress has been made in preventing and treating the infection.

Key Highlights

  • Overall ED visits for C. difficile infections decreased by 30% over the decade, indicating progress in infection control.
  • Use of metronidazole dropped from 66% to 30%, while vancomycin prescriptions increased by 80%, reflecting updated treatment guidelines.
  • Incidence rates among 18-24-year-olds rose by 59%, suggesting changing epidemiology and risk factors.
  • More infections are occurring outside hospital settings, pointing to a shift in where and how the infection develops.
  • Some ED staff may not be fully adhering to new treatment guidelines, as indicated by continued metronidazole use.

Fewer patients are going to emergency departments for C difficile infections in the U.S. from 2014 to 2024, according to a study published last week. CIDRAP has the news.

The potentially deadly infection is diagnosed almost half a million times per year in the U.S., and "most infections occur while or after taking antibiotics." However, the overall incidence declined from 2.94 per 1,000 ED visits to 2.07 over the study period, which represents a "relative decline of 30%." However, incidence rates did jump 59% among people aged 18 to 24.

A growing number of people in recent years have "developed the infection outside the hospital." Numbers may be going down in hospitals themselves because ED staff have changed the way they treat the infection.

Prescriptions for the antibiotic metronidazole fell from 66% to 30%, which reflects changes in recommendations from medical organizations. Vancomycin was recommended instead, and use of that drug increased 80% over the period of the study. Continuing use of metronidazole "suggests that emergency department staff aren't following guidelines closely enough."

About the Author

Matt MacKenzie

Associate Editor

Matt is Associate Editor for Healthcare Purchasing News.

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